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Dr. Marco Antonio Loza Mejía

Summary

Summary:

Full academic degree:

Ph.D in Chemical Science

Nationality:

Mexican

I+D+i groups to which he belongs:

Design, Isolation, and Synthesis of Bioactive Molecules

Topics of his interest:

  • Computer-Aided Drug Design
  • Synthesis of Heterocyclic Compounds
  • Multitarget Drugs
  • Chronic Degenerative Diseases

About him:

He studied Pharmacy Chemist in Universidad La Salle, completed Master’s and Ph.D. studies in the Department of Pharmacy at the National Autonomous University of Mexico (UNAM), including a doctoral stay at the University of Alcalá de Henares (Madrid) and a scholarship for the prestigious Residential School on Medicinal Chemistry at Drew University (New Jersey). Currently, he is a Full-Time Professor-Researcher at his Alma Mater since 2008, where he leads the Research Group in the Design, Isolation, and Synthesis of Bioactive Molecules. He has taught courses in Organic Chemistry, Pharmacology, Drug Development, and Protocol Development at the undergraduate and postgraduate levels. He supported knowledge dissemination during the pandemic through a YouTube channel (https://www.youtube.com/@profemarcoloza/videos). He has published over 25 articles in high-impact international peer-reviewed journals, with his work receiving over 300 citations. Over 60 students have been part of his research group, engaging in activities such as Social Service, Short Stays, and Theses. He participates in supervisory committees for Master’s and Ph.D. programs at the Instituto Politécnico Nacional, Universidad Autónoma de Querétaro, and the Universidad Autónoma Metropolitana. He is a member of the National Researchers System Level I, and his current research interests focus on drug development for chronic-degenerative conditions.

Conferences

Conferences:

Scientific Speeches:

  • Loza Mejía, M.A. CALIBAJA WEBINAR SERIES FALL 2021. Design and evaluation of drugs against metabolic syndrome: Use of a holistic model for the evaluation of their multitarget properties (November, 2021)
  • Loza Mejía, M.A. Diseño y evaluación de compuestos multitarget con diferentes aplicaciones terapéuticas (November, 2020) (link: https://www.youtube.com/live/N039MAKs350).
  • Loza Mejía, M.A. CONVERSATORIO QUÍMICO DE LA SOCIEDAD QUÍMICA DE PANAMÁ. Diseño asistido por computadora de antivirales multi-target para el tratamiento de COVID-19 (August, 2020 )(link:  https://youtu.be/h4tdJ-J19NE).
  • Loza Mejía, M.A. Prospección in silico de Ligandos con Potencial Acción Multitarget hacia Blancos Terapéuticos del Glaucoma. XXI Concurso Lasallista de Investigación, Desarrollo e innovación (October 9, 2019) Universidad La Salle.
  • Loza Mejía, M.A. Diseño y evaluación in silico de nuevos antipalúdicos multitarget como alternativa terapéutica a la artemisina (October 9, 2019) XXI Concurso Lasallista de Investigación, Desarrollo e innovación. Universidad La Salle.
  • Loza Mejía, M.A. CLINICAL RESEARCH INSIDER SUMMIT. Investigación y desarrollo de moléculas desde las universidades: lecciones aprendidas. (link: https://issuu.com/clinicalresearchinsider/docs/clinical_research_insider_summit_no_11_eng)

Outreach speeches:

  • Loza Mejía, M.A. Curso Tópicos Avanzados de Quimica Farmacéutica. Summer reseach stay July 2019.
  • Loza Mejía, M.A. Taller Quimioinformática. XXXIV Academic Conferences in Chemical Sciences. September 2019

Publications

Publications:

Indexed articles:

  • Chávez-Gutiérrez, E.; Martínez-Arellanes, M.; Murillo-López, M.; Medina-Guzmán, M.F.; Mobarak-Richaud, L.; Pelcastre-Guzmán, K.; Quintana-Romero, O.J.; Ariza-Castolo, A.; Ayala-Moreno, M.d.R.; Salazar, J.R.; et al. (2022) In Combo Studies for the Optimization of 5-Aminoanthranilic Acid Derivatives as Potential Multitarget Drugs for the Management of Metabolic Syndrome. Pharmaceuticals, 15, 1461. https://doi.org/10.3390/ph15121461
  • Saldivar-Cerón HI, Villamar-Cruz O, Wells CM, Oguz I, Spaggiari F, Chernoff J, Patiño-López G, Huerta-Yepez S, Montecillo-Aguado M, Rivera-Pazos CM, Loza-Mejía MA, Vivar-Sierra A, Briseño-Díaz P, Zentella-Dehesa A, Leon-Del-Rio A, López-Saavedra A, Padierna-Mota L, Ibarra-Sánchez MdJ, Esparza-López J, Hernández-Rivas R and Arias-Romero LE (2022) p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/ Calmodulin-Dependent Protein Kinase II. Front. Cell Dev. Biol. 9:759259. https://doi.org/10.3389/fcell.2021.759259
  • González-Álvarez, H.; Bravo-Jiménez, A.; Martínez-Arellanes, M.; Gamboa-Osorio, G.O.; Chávez-Gutiérrez, E.; González-Hernández, L.A.; Gallardo-Ignacio, K.; Quintana-Romero, O.J.; Ariza-Castolo, A.; Guerra-Araiza, C.; et al. (2021) In Silico-Based Design and In Vivo Evaluation of an Anthranilic Acid Derivative as a Multitarget Drug in a Diet-Induced Metabolic Syndrome Model. Pharmaceuticals, 14, 914. https://doi.org/10.3390/ph14090914
  • Vivar-Sierra, A.; Araiza-Macías, M.J.; Hernández-Contreras, J.P.; Vergara-Castañeda, A.; Ramírez-Vélez, G.; Pinto-Almazán, R.; Salazar, J.R.; Loza-Mejía, M.A. (2021) In Silico Study of Polyunsaturated Fatty Acids as Potential SARS-CoV-2 Spike Protein Closed Conformation Stabilizers: Epidemiological and Computational Approaches. Molecules, 26, 711. https://doi.org/10.3390/molecules26030711
  • Olga Villamar-Cruz, Marco A. Loza-Mejía, Luis E. Arias-Romero, Ignacio Camacho-Arroyo; (November 26, 2021) Recent advances in PTP1B signaling in metabolism and cancer. Biosci Rep; 41 (11): BSR20211994. doi: https://doi.org/10.1042/BSR20211994

Indexed articles in JCR (Journal Citation Report):

  • Salazar, J. R., Loza-Mejía, M. A., & Soto-Cabrera, D. (2020). Chemistry, biological activities and in silico bioprospection of sterols and triterpenes from Mexican columnar Cactaceae. In Molecules (Vol. 25, Issue 7). MDPI AG. https://doi.org/10.3390/molecules25071649
  • Sánchez-Tejeda, J. F., Sánchez-Ruiz, J. F., Salazar, J. R., & Loza-Mejía, M. A. (2020). A Definition of “Multitargeticity”: Identifying Potential Multitarget and Selective Ligands Through a Vector Analysis. Frontiers in Chemistry, 8. https://doi.org/10.3389/fchem.2020.00176
  • Maldonado, V.; Loza-Mejía, MA; Chávez-Alderete, J. (2020) Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19. Medical Hypothesis, 144, 109988.

Indexed articles in CRMCyT (Mexican Index of Reseach Journals of CONACYT):

  • Loza-Mejía, M., & Salazar, J. (2020) In silico exploration through molecular docking and molecular dynamics of some cinnamoyl substituted compounds on targets related to SARS-CoV-2. Revista Del Centro De Investigación De La Universidad La Salle, 14(53), 67-88. https://repositorio.lasalle.mx/handle/lasalle/1886

Institutional production:

  • Puertas Santamaría, E.F., Mancha Meléndez, F.M., Ramírez Martínez, A., Fierro Dávila, U., Espinosa Alarcón, C.A., Loza Mejía, M.A. (2019) Prospección in silico de Ligandos con Potencial Acción Multitarget hacia Blancos Terapéuticos del Glaucoma. Memorias del Concurso Lasallista de Investigación, Desarrollo e innovación. Vol 6, SAL-1.
  • Férnandez Rosas, S., Gómez Ramírez, A.P., Loza-Mejía, M.A. (2019) Diseño y evaluación in silico de nuevos antipalúdicos multitarget como alternativa terapéutica a la artemisina. Memorias del Concurso Lasallista de Investigación, Desarrollo e innovación. Vol 6, SAL-1, SAL-13
  • Trujillo Hidalgo, J.E., González Reséndiz, K., Rodriguez Nuño, I.G., Sánchez Tejeda, M.G., Oblea Postigo, J., Loza-Mejía, M.A. (2019) Diseño in-silico de ligandos de RAR-γ para el tratamiento de acné severo con menor incidencia de efectos neurológicos. Memorias del Concurso Lasallista de Investigación, Desarrollo e innovación. Vol 6, SAL-1, NEC-23
  • Alejandro Islas-García y A. Loza-Mejía. Memorias del 13° Encuentro Estudiantil de Investigación, Desarrollo e innovación “Dra. Araceli Sánchez de Corral”.

Gallery

Gallery:

✉: marcoantonio.loza@lasalle.mx
🕿: 55 5278 9500 Ext. 2720
Belongs to SNI (National System of Researchers) Level I
🖥 ResearchGate
🖥 Google Scholar
🖥 ORCID